HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(Quinolin-4-yl)ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-(Pyridin-3-yl)ethan-1-amine | HCID 2771688 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 1-(Quinolin-4-yl)ethan-1-one | HCID 12340190 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(Quinolin-4-yl)ethan-1-amine | HCID 10844927 | — |
Reaction Steps
The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 1-quinolin-4-yl-ethanone, (1.71 g, 10 mmol, Aldrich), 2 M ammonia solution in methyl alcohol, (40 mL, 80 mmol, Aldrich), acetic acid (10 mL, J. T. Baker) and sodium cyanoborohydride (5.0 g, 80 mmol, Aldrich). The title compound obtained in form as light yellow solid in 100% yield (1.72 g, 10 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196102B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-ea0da7b2c4ff4b8eaf91c579379fee94 |
| Source note | uspto-grants-2007_03 |