HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1-(1-Methyl-1H-indol-4-yl)-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-(Quinolin-4-yl)ethanol | HCID 5314755 | — |
| Reactant | 1-Methyl-1H-indole-4-carbaldehyde | HCID 17221111 | — |
| Reactant | HCID 178418373 | HCID 178418373 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(1-Methyl-1H-indol-4-yl)-ethanol | HCID 22391398 | — |
Reaction Steps
The title compound was prepared by the same procedure for 1-quinolin-4-yl-ethanol from 1-methyl-1H-indole-4-carbaldehyde (2.8 g, 17.6 mmol), 3 M methyl magnesium iodide solution in diethyl ether (10 mL, 30 mmol, Aldrich) and anhydrous tetrahydrofuran (20 mL). The crude title compound obtained in form as yellow oil in 97% yield (3.0 g, 17.1 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196102B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-13aa84f089614efbbdef2fd8f4b381dc |
| Source note | uspto-grants-2007_03 |