Acetic Acid → HCID 131724211, compound

Participants

Reaction Steps

To a stirred solution of 6-bromo-2-pyridine-carboxaldehyde (200 mg, 1.08 mmol) in dichloroethane (10 mL) was added morpholine (0.14 mL, 1.62 mmol) followed by NaBH(OAc)3 (458 mg, 2.16 mmol) and AcOH (0.25 mL, 4.32 mmol). The resulting mixture was stirred at RT for 12 h. The reaction was quenched with 2M Na2CO3 solution and stirred 1 h. The mixture was poured into Et2O and washed with 2 M Na2CO3 solution. The organic layer was collected, dried over Na2SO4 and concentrated in vacuo to give 2-bromo-6-morpholinyl-methylpyridine as a white solid. MS m/z: 256.9 (M+H).

Provenance & Evidence