Ammonium Hydroxide → HCID 18772066, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of N-{1-[(diethylamino)-methyl]-2-methylpropyl}(tert-butoxy)-N-[(6-bromo(2-pyridyl))methyl]carboxamide (5 mg, 0.012 mmol) in IpOH (5 ML) in a sealed tube, was added NH4OH (28–30% 6 mL) followed by excess Cu. The resulting solution was heated under pressure at 90° C. for 24 h. The mixture was brought to RT, diluted with H2O (10 mL) and extracted with CHCl3 (3×20 mL) The organic layers were combined, dried over MgSO4, filtered and concentrated by rotary evaporation to afford the title compound as a green oil. No purification was required. EI-MS m/z 365 (M+H).

Provenance & Evidence