Propylamine → HCID 18772120, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of N-[2-(4-pyridinyl)-4-thiazolyl]-N′-2-[6-(piperidon-4-yl)methyl]urea (50 mg, 0.12 mmol, Example 175) in MeOH (10 mL) was added propylamine (0.1 mL, 1.22 mmol). The resulting mixture was heated at 50° C. for 4 h under N2. After the mixture was cooled to RT, NaBH4 (83 mg, 2.20 mmol) was added. The mixture was stirred at RT under N2 for 3 h. Solvent was removed in vacuo and the crude product was purified by chromatography on silica gel. Elution with CH2Cl2:MeOH (90:10) gave the title compound as a white solid. MS m/z: 451.7 (M+H). Calc'd. for C23H29N7OS-451.6.

Provenance & Evidence