Ethanolamine → HCID 18772153, compound

HRID 460243Notes

Reaction equation

HRID 460243 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[CH2:30]([CH2:32][NH2:33])[OH:31]>CO>[OH:31][CH2:30][CH2:32][NH:33][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 18771820HCID 18771820, compound

Product 1

HCID 18772153HCID 18772153, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[2-(4-Pyridinyl)-4-thiazolyl]-N′-2-[6-(piperidon-4-yl)methyl]urea (60 mg, 0.147 mmol, Example 175) and ethanolamine (0.09 mL, 1.47 mmol) were heated in MeOH (10 mL) yielded the title compound as pale yellow solid. MS m/z: 454.6 (M+H). Calc'd. for C22H27N7O2S-453.57.

Sources & evidence

ORD record
ord-b75896a92b3a460c89082f5c2e550ad1
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

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