HCID 18771682, compound → HCID 18771992, compound

Participants

Reaction Steps

LiAlH4 (3 mg, 0.079 mmol) was added to a solution of methyl 1-{6-[3-(2-pyridin-4-yl-thiazol-4-yl)ureido]-pyridin-2-ylmethyl}-pyrrolidine-2-carboxylate (15 mg, 0.034 mmol, Example 77) in THF (5 mL) at RT and the resulting mixture was stirred for 8 h. A precipitate formed and was collected. The solid was dissolved in CHCl3 (5 mL) and washed with saturated NaHCO3 solution (5 mL). The aqueous layer was adjusted to pH 7 with 1N HCl and extracted with CHCl3. The organics were combined, dried over MgSO4 and concentrated in vacuo to give a pale yellow solid. MS m/z: 411.1 (M+H). Calc'd for C20H22N6O2S-410.50.

Provenance & Evidence