Trifluoroacetic acid → HCID 18771712, compound

Participants

Reaction Steps

6-[3-(2-Pyridin-4-yl-thiazol-4-yl)-ureido]-3′,6′-dihydro-2′H-[2,4]bipyridinyl-1′-carboxylic acid tert-butyl ester was suspended in CH2Cl2 (10 mL) and treated with TFA (5 mL). Stirred at RT for 30 min. Quenched with saturated NaHCO3 and filtered yellow solid. Washed solid with H2O and MeOH to give 1-(2-pyridin-4-yl-thiazol-4-yl)-3-(1′,2′,3′,6′-tetrahydro-[2,4′]bipyridinyl-6-yl)-urea as a yellow solid. MS m/z: 379.1 (M+H). Calc'd for C19H18N6OS-378.45.

Provenance & Evidence