3-Thiophen-2-ylprop-2-enoic acid → 3-(2-Thienyl)propanoic acid

HRID 460361Notes

Reaction equation

HRID 460361 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([OH:10])=[O:9]>CO.[Pd]>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=[O:9]

Participants

4

Reactant 1

HCID 928683-Thiophen-2-ylprop-2-enoic acid

Product 1

HCID 7031693-(2-Thienyl)propanoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 3-thiophene-2-yl-acrylic acid (Intermediate AB) (2.00 g, 0.01299 mol), 10% Pd on C (2.00 g) in methanol (200 mL) was stirred under the atmosphere of H2 (50 PSI) for 18 h. The resulting system was purged with N2 and then filtered through a pad of celite. Organics were dried over MgSO4 and the solvent was removed in vacuo to provide 3-thiophene-2-yl-propionic acid.

Workup

  1. customThe resulting system was purged with N2
  2. filtrationfiltered through a pad of celite
  3. dry with materialOrganics were dried over MgSO4
  4. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-350dd523319545f38984ca6f137f3a3b
Source dataset
uspto-grants-2007_03
Patent number
US07196110B2

Reaction notes

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