Methanesulfonic Acid → HCID 20634976, compound

Participants

Reaction Steps

To a solution of 1,4-bis[5-(4-chloro-3,5-dimethoxyphenyl)-2-pyridyl]hexahydro-1,4-diazepine (130.0 mg, 0.210 mmol) in methanol (5.0 mL) was added a 1.0 M aqueous methanesulfonic acid (0.45 mL, 0.45 mmol), and the reaction mixture was concentrated under reduced pressure. Ethanol (5.0 mL) was added to the residue, and the resulting mixture was concentrated under reduced pressure. The residue seas recrystallized from methanol-chloroform-diethyl ether to yield the title compound as a colorless crystalline powder (melting point: 279.0–282.0° C.)(138.0 mg, yield: 83%).

Provenance & Evidence