Dichloromethane → Acetophenone

Temperature

0 °C

To a freshly prepared CH2Cl2 solution of chromyl diacetate (O2Cr(OAc)2, 1 mL, 1 M) was added dropwise a CH3CN solution of H5IO6 (0.33 M, 3 mL) at −40° C. for 10 minutes to give a deep orange solution which is stable at −40° C. for several hours. In a different flask, a CH2Cl2 (0.4 mL) solution of ethyl benzene (212 mg, 2 mmol) and acetic anhydride (0.38 mL, 4 mmol, 2 eq) was cooled to −40° C. The earlier prepared chromium oxidant solution (0.4 mL, 0.25 M. 5 mol %) was added in one portion to the solution of starting material, followed; by the addition of a CH3CN solution of H5IO6 (0.33 M, 18.2 mL, 3 eq) at −40° C. over a period of 30 minutes. The resulting orange colored reaction mixture was gradually warmed up to 0° C. for a period of 1.5 h, quenched by addition of saturated aqueous Na2SO4, extracted with EtOAc, washed with water, brine, dried over Na2SO4, concentrated and purified by silica gel column chromatography to give acetophenone (231 mg, 96%).

1. customto give a deep orange solution which
2. waitis stable at −40° C. for several hours
3. additionwas added in one portion to the solution of starting material
4. customquenched by addition of saturated aqueous Na2SO4
5. extractionextracted with EtOAc
6. washwashed with water, brine
7. dry with materialdried over Na2SO4
8. concentrationconcentrated
9. custompurified by silica gel column chromatography

ORD record

ord-7127673950334696b1719ddd949e412e

Source dataset

uspto-grants-2007_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07196191B2