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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 46047Generated: October 26, 2026

Ethyl 1-bromocyclobutanecarboxylate → 6-[(2,2,3,3-tetramethylcyclopropyl)amino]-5-thia-7-azaspiro[3.4]oct-6-en-8-one

https://huagongshe.com/reaction/46047

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 1-bromocyclobutanecarboxylateHCID 97595—
ReactantN-(2,2,3,3-tetramethylcyclopropyl)thioureaHCID 79006986—
Product6-[(2,2,3,3-tetramethylcyclopropyl)amino]-5-thia-7-azaspiro[3.4]oct-6-en-8-oneHCID 178428351—

Reaction Steps

Synthesis was performed from N-(2,2,3,3-tetramethylcyclopropyl)thiourea and ethyl 1-bromocyclobutanecarboxylate according to Method D.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08541592B2
Source datasetuspto-grants-2013_09
ORD IDord-064c10a8730a4507b8c96360c606469f
Source noteuspto-grants-2013_09