HRID460472

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)OCC

HCID12043782

未命名化合物

结构：C=CC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12

HCID69414807

未命名化合物

PRODUCTS

生成物

结构：C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)O)[C@H]3[C@@H]1CC[C@@H]2O

HCID53323790

10-[3,17beta-Dihydroxyestra-1,3,5(10)-trien-7alpha-yl]-2-(4,4,5,5,5-pentafluoropentyl)decanoic acid

C33H47F5O4

PROCEDURE

实验过程

Starting with the 3-methoxy-7α-(2-propenyl)estra-1,3,5(10)-trien-17β-ol prepared in Example 13 and ethyl 2-(4,4,5,5,5-pentafluoropentyl)-8-nonenoate prepared separately, the same procedure as shown in Example 13 was repeated to give 10-[3,17β-dihydroxyestra-1,3,5(10)-trien-7α-yl]-2-(4,4,5,5,5-pentafluoropentyl)decanoic acid.

WORKUP

后处理

customprepared separately

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4f862272e0844cedaf7158fc4cf18e1a
来源数据集: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07196081B2
来源说明: uspto-grants-2007_03

反应 SMILES

C[O:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@H:8]([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C@@H:12]([OH:21])[CH2:11][CH2:10]4)[C@H:7]([CH2:22]C=C)[CH2:6][C:5]=2[CH:4]=1.[F:25][C:26]([F:47])([C:43]([F:46])([F:45])[F:44])[CH2:27][CH2:28][CH2:29][CH:30]([CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH:41]=[CH2:42])[C:31]([O:33]CC)=[O:32]>>[OH:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@H:8]([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C@@H:12]([OH:21])[CH2:11][CH2:10]4)[C@H:7]([CH2:22][CH2:42][CH2:41][CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH:30]([CH2:29][CH2:28][CH2:27][C:26]([F:25])([F:47])[C:43]([F:44])([F:45])[F:46])[C:31]([OH:33])=[O:32])[CH2:6][C:5]=2[CH:4]=1