HRID460482

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)OCC

HCID12043786

Ethyl 2-(4,4,5,5,5-pentafluoropentyl)-9-decenoate

C17H27F5O2

结构：C=CCC1=C2c3ccc(OCc4ccccc4)cc3CC[C@H]2[C@@H]2CC[C@H](OCc3ccccc3)[C@@]2(C)C1

HCID69413225

未命名化合物

PRODUCTS

生成物

结构：C[C@]12C[C@H](CCCCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)O)[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O

HCID86588535

未命名化合物

PROCEDURE

实验过程

Starting with the 3,17β-bis(benzyloxy)-11-(2-propenyl)estra-1,3,5(10),9(11)-tetraene prepared in Example 20 and ethyl 2-(4,4,5,5,5-pentafluoro-pentyl)-9-decenoate prepared separately, the same procedure as shown in Example 20 was repeated to give 11-(3,17β-dihydroxyestra-1,3,5(10)-trien-11β-yl)-2-(4,4,5,5,5-pentafluoropentyl)undecanoic acid.

WORKUP

后处理

customprepared separately

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cdcd4d9a99e74620b5b2dbc7fd5a4a1e
来源数据集: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07196081B2
来源说明: uspto-grants-2007_03

反应 SMILES

C([O:8][C:9]1[CH:26]=[CH:25][C:24]2[C:23]3[C@H:14]([C@H:15]4[C@@:19]([CH2:21][C:22]=3[CH2:27]C=C)([CH3:20])[C@@H:18]([O:30]CC3C=CC=CC=3)[CH2:17][CH2:16]4)[CH2:13][CH2:12][C:11]=2[CH:10]=1)C1C=CC=CC=1.[F:38][C:39]([F:61])([C:57]([F:60])([F:59])[F:58])[CH2:40][CH2:41][CH2:42][CH:43]([CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH:55]=[CH2:56])[C:44]([O:46]CC)=[O:45]>>[OH:8][C:9]1[CH:26]=[CH:25][C:24]2[C@@H:23]3[C@H:14]([C@H:15]4[C@@:19]([CH2:21][C@@H:22]3[CH2:27][CH2:56][CH2:55][CH2:54][CH2:53][CH2:52][CH2:51][CH2:50][CH2:49][CH:43]([CH2:42][CH2:41][CH2:40][C:39]([F:38])([F:61])[C:57]([F:58])([F:59])[F:60])[C:44]([OH:46])=[O:45])([CH3:20])[C@@H:18]([OH:30])[CH2:17][CH2:16]4)[CH2:13][CH2:12][C:11]=2[CH:10]=1