6-Methoxy-2-(4-methoxyphenyl)-1-(2-propenyl)naphthalene → 12-[6-Hydroxy-2-(4-hydroxyphenyl)naphth-1-yl]-2-(4,4,5,5,5-pentafluoropentyl)dodecanoic acid

HRID 460483Notes

Reaction equation

HRID 460483 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([CH2:13]C=C)=[C:8]([C:16]1[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=1)[CH:7]=[CH:6]2.[CH2:24]([C:33]([CH2:44][CH2:45][CH2:46][C:47]([F:53])([F:52])[C:48]([F:51])([F:50])[F:49])([C:39]([O:41]CC)=[O:40])C(OCC)=O)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH:31]=[CH2:32]>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([CH2:13][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH:33]([CH2:44][CH2:45][CH2:46][C:47]([F:52])([F:53])[C:48]([F:49])([F:50])[F:51])[C:39]([OH:41])=[O:40])=[C:8]([C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=1)[CH:7]=[CH:6]2

Participants

3

Reactant 2

HCID 227180106-Methoxy-2-(4-methoxyphenyl)-1-(2-propenyl)naphthaleneHCID 22718058HCID 22718058, compound

Product 1

HCID 2271804612-[6-Hydroxy-2-(4-hydroxyphenyl)naphth-1-yl]-2-(4,4,5,5,5-pentafluoropentyl)dodecanoic acid

Procedure

Starting with 6-methoxy-2-(4-methoxyphenyl)-1-(2-propenyl)naphthalene and separately prepared diethyl 2-(8-nonenyl)-2-(4,4,5,5,5-pentafluoropentyl)malonate, the same procedures as shown in Examples 1, 2 and 3 were repeated to give 12-[6-hydroxy-2-(4-hydroxyphenyl)naphth-1-yl]-2-(4,4,5,5,5-pentafluoropentyl)dodecanoic acid.

Sources & evidence

ORD record
ord-198c3d64973d4ff9afe855e400200974
Source dataset
uspto-grants-2007_03
Patent number
US07196081B2

Reaction notes

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