참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzenepropanoic acid | HCID 107 | — |
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Metaperiodic acid | HCID 65185 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-(4-Iodophenyl)propanoic acid | HCID 233238 | 460.8% |
반응 단계
Hydrocinnamic acid is iodinated to form 4-iodohydrocinnamic acid. The process is performed by mixing 201.2 g hydrocinnamic acid, 1 L acetic acid, 152 mL water, 52.8 g periodic acid, 76 mL sulfuric acid, and 144 g iodine. The mixture is heated at 105° C. for 6.5 hours. Next, 200 mL water is added, and the mixture is cooled to room temperature overnight. The solid product in the resultant mixture is filtered and washed with water, yielding 350 g unpurified 4-iodohydrocinnamic acid. Further purification is not necessary and is not conducted, and the product is used as is in the second step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07196214B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_03 |
|---|
| ORD ID | ord-c4543b6f2743498eaf89c9a303be194c |
|---|
| 출처 메모 | uspto-grants-2007_03 |
|---|
