HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarbothioamide | HCID 13402923 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide | HCID 13391621 | — |
Reaction Steps
1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.44 g (6 mmol) of methyl isothiocyanate are added, and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete precipitation and the precipitate formed is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04727081 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-0232d71524f549e7b83bb9e370978819 |
| Source note | uspto-grants-1988_02 |