Phosphorus oxychloride → HCID 69435062, compound

Participants

Reaction Steps

2.5 g of 6-[[1-(4-methylphenyl)-2-oxo-2,3-dihydro-1H-benzoimidazol-6-yl]oxy]hexanoic acid methyl ester was mixed with 10 ml of phosphorus oxychloride, and the mixture was refluxed for 2 hours. After cooling, it was stirred into saturated sodium bicarbonate solution, extracted three times with ethyl acetate, the combined organic phases were dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 1.28 g was obtained.

Provenance & Evidence