反应详情

200 mg of 6-(3-phenylamino-4-aminophenyl)oxyhexanoic acid methyl ester was dissolved in 1 ml of 1,2-dichloroethane, the solution was mixed with 85 μl of phenylisocyanide dichloride, and the mixture was heated for 6 hours to 65° C. After cooling, it was mixed with water, extracted three times with ethyl acetate, the combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 55 mg was obtained.

1. temperaturethe mixture was heated for 6 hours to 65° C
2. temperatureAfter cooling
3. extractionextracted three times with ethyl acetate
4. washthe combined organic phases were washed with saturated sodium chloride solution
5. customdried on sodium sulfate
6. concentrationconcentrated by evaporation in a vacuum
7. customThe residue was purified by column chromatography on silica gel
8. custom55 mg was obtained