Thiophenol → HCID 69434718, compound

Participants

Reaction Conditions

Reaction Steps

150 mg of 6-[[2-chloro-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 2 ml of dimethylformamide, mixed with 54 mg of potassium carbonate and 40 μl of thiophenol, and the mixture was stirred for 5 hours at 140° C. After cooling, it was mixed with saturated ammonium chloride solution, diluted with water, extracted three times with ethyl acetate, the combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. 158 mg was obtained.

Provenance & Evidence