HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 460540Generated: October 25, 2026
Benzyl Bromide → 6-[(2-Benzylmercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]Hexanoic Acid Methyl Ester
https://huagongshe.com/reaction/460540
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Reactant | HCID 178500329 | HCID 178500329 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[(2-Benzylmercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]Hexanoic Acid Methyl Ester | HCID 69431600 | — |
Reaction Steps
490 mg of 6-[(2-mercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]hexanoic acid methyl ester was dissolved in 7 ml of N,N-dimethylformamide, mixed with 0.19 ml of benzyl bromide, 278 mg of potassium bicarbonate and 49 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 548 mg was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07196202B2 |
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| Source dataset | uspto-grants-2007_03 |
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| ORD ID | ord-8abc5b1a4f2148129202671593cb4dc2 |
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| Source note | uspto-grants-2007_03 |
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