Ethyl 4-benzyloxy-1-methylindole-2-carboxylate → Ethyl 4-hydroxy-1-methyl-1H-indole-2-carboxylate

Participants

Reaction Steps

To a solution (200 ml) of ethyl 4-benzyloxy-1-methylindole-2-carboxylate (13.0 g) in ethanol was added 10% palladium-carbon (1.3 g), and the mixture was stirred at room temperature for 8 hr under a hydrogen atmosphere. The palladium-carbon was filtered off with celite and the reaction mixture was concentrated under reduced pressure to give the title compound (8.0 g) as a brown oil.

Provenance & Evidence