Boron tribromide → 3-(4-Hydroxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole

HRID 460567Notes

Reaction equation

C[O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]3[N:16]=[C:15]([CH3:17])[O:14][N:13]=3)[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.B(Br)(Br)Br>>[OH:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]3[N:16]=[C:15]([CH3:17])[O:14][N:13]=3)[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 227291663-(4-Methoxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole

Product 1

HCID 1357943063-(4-Hydroxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazoleYield 72.6%

Procedure

By the reactions in the same manner as in Starting Material Synthesis Example 5 using 3-(4-methoxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole (1.1 g) and boron tribromide (4.2 ml), the title compound (0.75 g) was obtained as yellow crystals.

Sources & evidence

ORD record: ord-f330f0d6bea74224baf7c0252141faaf
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07196199B2

Reaction notes

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