HCID 22729049, compound → HCID 135794326, compound

HRID 460578Notes

Reaction equation

HRID 460578 reaction equation
COC[O:4][C:5]1[C:13]2[CH:12]=[C:11]([C:14]3[O:15][C:16]([CH3:19])=[N:17][N:18]=3)[S:10][C:9]=2[CH:8]=[CH:7][CH:6]=1>C(O)(=O)C.O>[OH:4][C:5]1[C:13]2[CH:12]=[C:11]([C:14]3[O:15][C:16]([CH3:19])=[N:17][N:18]=3)[S:10][C:9]=2[CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 1

HCID 22729049HCID 22729049, compound

Product 1

HCID 135794326HCID 135794326, compoundYield 119%

Reagents, catalysts & solvents 1

HCID 21899381Acetic acid--water (1/1)Solvent

Conditions

Temperature
80 °C

Procedure

2-(4-(Methoxymethyloxy)benzo(b)thiophen-2-yl)-5-methyl-1,3,4-oxadiazole (1.4 g) was dissolved in a mixed solvent (10 ml) of acetic acid-water (1:1) and the mixture was heated at 80° C. for 4 hr. The reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oily compound (1.4 g).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3861bc6339ec47169cc0e022ab67e410
Source dataset
uspto-grants-2007_03
Patent number
US07196199B2

Reaction notes

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