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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 460614Generated: October 29, 2026

N-propargyl-4-(methoxymethyloxy)benzo(b)thiophene-2-carboxamide → 4-Hydroxy-2-(5-methyloxazol-2-yl)benzo(b)thiophene

https://huagongshe.com/reaction/460614

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-propargyl-4-(methoxymethyloxy)benzo(b)thiophene-2-carboxamideHCID 22729210—
CatalystMercurous acetateHCID 61181—
Product4-Hydroxy-2-(5-methyloxazol-2-yl)benzo(b)thiopheneHCID 13579431147.8%

Reaction Steps

By the reactions in the same manner as in Starting Material Synthesis Example 5 using N-propargyl-4-(methoxymethyloxy)benzo(b)thiophene-2-carboxamide (6.00 g) and mercury acetate (765 mg), the title compound (2.41 g) was obtained as yellow crystals, melting point 188–189° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07196199B2
Source datasetuspto-grants-2007_03
ORD IDord-313340e57ca94765817358a6ee19568b
Source noteuspto-grants-2007_03