Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → (S)-alpha-(2'-(2,3-epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-(2-Hydroxybenzylidene)dihydrofuran-2(3h)-one | HCID 229758 | — |
| 반응물 | (S)-(+)-Glycidyl-4-nitrobenzoate | HCID 10868995 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (S)-alpha-(2'-(2,3-epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone | HCID 86585643 | 70.8% |
반응 단계
To α-(2′-hydroxybenzylidene)-γ-butyrolactone (60 g) were added dimethylformamide (600 ml) and potassium carbonate (87 g) and (S)-glycidyl nosylate (82 g) was added. The reaction mixture was stirred for 2 days at room temperature. The reaction mixture was concentrated under reduced pressure and water was added. The mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained crystals were recrystallized from ethyl acetate to give the title compound (55 g), melting point 68–70° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07196199B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-3dd7a5d4bd4b4d759e7efed18da46a03 |
| 출처 메모 | uspto-grants-2007_03 |