HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Chloro-3-fluorophenyl)piperidine → (S)-alpha-(2'-(3-(4-(4-chloro-3-fluorophenyl)piperidino)-2-hydroxypropyloxy)benzylidene)-gamma-butyrolactone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Chloro-3-fluorophenyl)piperidine | HCID 16679313 | — |
| Reactant | (S)-alpha-(2'-(2,3-epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone | HCID 86585643 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-alpha-(2'-(3-(4-(4-chloro-3-fluorophenyl)piperidino)-2-hydroxypropyloxy)benzylidene)-gamma-butyrolactone | HCID 69901488 | 33.7% |
Reaction Steps
By the reaction in same manner as in Example 307 using (S)-α-(2′-(2,3-epoxypropan-1-yloxy)benzylidene)-γ-butyrolactone (1.0 g) and 4-(4-chloro-3-fluorophenyl)piperidine (0.8 g) in methanol (50 ml), the title compound (0.58 g), melting point 114–115° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196199B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-319df2f82449400299a54d47a1c90779 |
| Source note | uspto-grants-2007_03 |