4-[4-Chloro-3-(trifluoromethyl)phenyl]piperidine → (S)-alpha-(2'-(3-(4-(4-chloro-3-trifluoromethylphenyl)piperidino)-2-hydroxypropyloxy) benzylidene)-gamma-butyrolactone Hydrochloride Monohydrate

Participants

Reaction Steps

The reaction was performed in same manner as in Example 307 using (S)-α-(2′-(2,3-epoxypropan-1-yloxy)benzylidene)-γ-butyrolactone (1.0 g) and 4-(4-chloro-3-trifluoromethylphenyl)piperidine (0.8 g) in methanol (50 ml), and the obtained oil was treated with methanol/hydrochloric acid to give the title compound (0.45 g), melting point 172–174° C.

Provenance & Evidence