反应详情

(S)-α-(2′-(2,3-Epoxypropan-1-yloxy)benzylidene)-γ-butyrolactone (1.2 g) and 4-(6-methoxynaphthalen-2-yl)piperidine (1.2 g) were dissolved in methanol (50 ml), and the mixture was refluxed under heating for 2 hr. After cooling, the solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (chloroform/methanol) to give the title compound (1.0 g), melting point 148–150° C.

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 2 hr
3. temperatureAfter cooling
4. customthe solvent was evaporated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (chloroform/methanol)