7-Cyclohexyl-6-[4-(3-trifluoromethyl-benzyloxy)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carbonitrile → HCID 178506161, compound

HRID 460699Notes

Reaction equation

HRID 460699 reaction equation
C1(C2N3N=CC(C#N)=C3N=CC=2C2C=CC(OCC3C=CC=C(C(F)(F)F)C=3)=CC=2)CCCCC1.[CH:36]1([C:42]2[N:47]3[N:48]=[CH:49][C:50]([C:51]4[NH:55][N:54]=[N:53][N:52]=4)=[C:46]3[N:45]=[CH:44][C:43]=2[C:56]2[CH:61]=[CH:60][C:59]([O:62][CH2:63][C:64]3[CH:69]=[CH:68][CH:67]=[C:66]([C:70]([F:73])([F:72])[F:71])[CH:65]=3)=[CH:58][CH:57]=2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1.N1C=NN=N1>>[CH:36]1([C:42]2[N:47]3[N:48]=[CH:49][C:50]([C:51]4[NH:55][N:54]=[N:53][N:52]=4)=[C:46]3[N:45]=[CH:44][C:43]=2[C:56]2[CH:57]=[CH:58][C:59]([O:62][CH2:63][C:64]3[CH:69]=[CH:68][CH:67]=[C:66]([C:70]([F:73])([F:72])[F:71])[CH:65]=3)=[CH:60][CH:61]=2)[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1

Participants

3

Reactant 2

HCID 184458837-Cyclohexyl-6-[4-(3-trifluoromethyl-benzyloxy)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carbonitrileHCID 178506162HCID 178506162, compound

Product 1

HCID 178506161HCID 178506161, compound

Procedure

Conversion of 7-cyclohexyl-6-[4-(3-trifluoromethyl-benzyloxy)-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carbonitrile to the corresponding tetrazole 7-cyclohexyl-3-(1H-tetrazol-5-yl)-6-[4-(3-trifluoromethyl-benzyloxy)-phenyl]-pyrazolo[1,5-a]pyrimidine (331) was accomplished via a procedure described elsewhere in this document.

Sources & evidence

ORD record
ord-d0f43a59e96f41e4941ef0a56e38f645
Source dataset
uspto-grants-2007_03
Patent number
US07196111B2

Reaction notes

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