反应详情

A solution of 1.0 g (7 mmol) of 5-amino-1H-pyrazole-3-carboxylic acid methyl ester in 10 mL of methanol (MeOH) in a sealed tube was saturated with ammonia (NH3), and the sealed tube mixture was stirred at rt overnight. Since analysis by thin layer chromatography (TLC) revealed that the reaction was not complete, the mixture was then heated at 80° for 1 day. The reaction mixture was then cooled, the sealed tube was opened, and the solvent was evaporated to give 0.9 g of desired 5-amino-1H-pyrazole-3-carboxylic acid amide as indicated by 1H NMR; LC-MS—calcd for C4H6N4O [M++H]+: 127.05, found: 127.2.

1. temperaturethe mixture was then heated at 80° for 1 day
2. temperatureThe reaction mixture was then cooled
3. customthe solvent was evaporated