Ammonia → HCID 178513689, compound

HRID 460720Notes

Reaction equation

HRID 460720 reaction equation
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([NH2:10])[NH:7][N:6]=1)=O.[NH3:11]>CO>[NH2:10][C:8]1[NH:7][N:6]=[C:5]([C:3]([NH2:11])=[O:2])[CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178498460HCID 178498460, compound

Product 1

HCID 178513689HCID 178513689, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1.0 g (7 mmol) of 5-amino-1H-pyrazole-3-carboxylic acid methyl ester in 10 mL of methanol (MeOH) in a sealed tube was saturated with ammonia (NH3), and the sealed tube mixture was stirred at rt overnight. Since analysis by thin layer chromatography (TLC) revealed that the reaction was not complete, the mixture was then heated at 80° for 1 day. The reaction mixture was then cooled, the sealed tube was opened, and the solvent was evaporated to give 0.9 g of desired 5-amino-1H-pyrazole-3-carboxylic acid amide as indicated by 1H NMR; LC-MS—calcd for C4H6N4O [M++H]+: 127.05, found: 127.2.

Workup

  1. temperaturethe mixture was then heated at 80° for 1 day
  2. temperatureThe reaction mixture was then cooled
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-7f060087cb0d4368ac2030d8505dbcc0
Source dataset
uspto-grants-2007_03
Patent number
US07196111B2

Reaction notes

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