4-(4-Chlorophenyl)-4-hydroxypiperidine → HCID 21394630, compound

Participants

Reaction Steps

A mixture of 10 g of 4-p-fluorophenyl-5-β-chloroethyl-4-thiazolin-2-one, 16.4 g of 4-hydroxy-4-(p-chlorophenyl)-piperidine, and a catalytic quantity of KI in 200 cc of toluene is heated in a closed tube for 35 hours. The solid present is filtered off and the filtrate is shaken with a 1:1 solution of HCl. A solid precipitates and is dissolved in acetone and recrystallised. M.P. = 192° C (from alcohol).

Provenance & Evidence