Carbamic acid, methylthio-, O-ethyl ester → HCID 53685992, compound

HRID 460766Notes

Reaction equation

HRID 460766 reaction equation
[C:1]([CH:9](Br)[CH2:10][CH2:11][Cl:12])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:14][NH:15][C:16](=[S:20])[O:17]CC>O1CCOCC1>[CH3:14][N:15]1[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:9]([CH2:10][CH2:11][Cl:12])[S:20][C:16]1=[O:17]

Participants

4

Reactant 2

HCID 5365210Carbamic acid, methylthio-, O-ethyl esterHCID 202266952-Bromo-4-chloro-1-phenylbutan-1-one

Product 1

HCID 53685992HCID 53685992, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The 3-methyl-4-phenyl-5-β-chloroethyl-4-thiazolin-2-one is prepared in the following manner. A solution of 21.9 g of 1-benzoyl-1-bromo-3-chloropropane and 5 g of ethyl N-methyl-thiocarbamate in 50 cc of dioxan is heated under reflux for 10 hours, and then evaporated to dryness under reduced pressure, M.P. = 88°-90° C (from hexane).

Workup

  1. temperatureunder reflux for 10 hours
  2. customevaporated to dryness under reduced pressure, M.P. = 88°-90° C (from hexane)

Sources & evidence

ORD record
ord-0d9b4d975bcd44089a07243b51c2491b
Source dataset
uspto-grants-1977_12
Patent number
US04061637

Reaction notes

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