2-Bromo-4-chloro-1-phenylbutan-1-one → HCID 54145555, compound

HRID 460767Notes

Reaction equation

HRID 460767 reaction equation
[C:1]([CH:9](Br)[CH2:10][CH2:11][Cl:12])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:14][NH:15][C:16](=[S:18])[S-:17].C[NH3+]>>[CH3:14][N:15]1[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:9]([CH2:10][CH2:11][Cl:12])[S:18][C:16]1=[S:17]

Participants

3

Reactant 2

HCID 202266952-Bromo-4-chloro-1-phenylbutan-1-oneHCID 7355561921160-95-2

Product 1

HCID 54145555HCID 54145555, compound

Procedure

The 3-methyl-4-phenyl-5-β-chloroethyl-4-thiazoline-2-thione is prepared in the following manner: A solution of 33 g of 1-benzoyl-1-bromo-3-chloropropane in 150 cc of absolute alcohol is added slowly to a suspension of 20 g of methyl ammonium N-methyldithiocarbamate in 150 cc of absolute alcohol. The mixture is agitated for 2 hours at ambient temperature and the solvent is then evaporated under reduced pressure. The residue is redissolved in chloroform, washed with water and the separated organic phase is dried over Na2SO4 and then evaporated to dryness.

Workup

  1. customthe solvent is then evaporated under reduced pressure
  2. dissolutionThe residue is redissolved in chloroform
  3. washwashed with water
  4. dry with materialthe separated organic phase is dried over Na2SO4
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-89af0c251e0f45e1ab599a0d8ab0932f
Source dataset
uspto-grants-1977_12
Patent number
US04061637

Reaction notes

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