Formaldehyde → HCID 21394499, compound

Participants

Reaction Conditions

Reaction Steps

19.1 g (0.1 mole) of 2,2,6,6-tetramethyl-1-aza-4-thiacyclohexane-4,4-dioxide is added, with ice cooling, to 20 ml of 5N hydrochloric acid; 6.5 g of potassium cyanide is added and then in ca. 20 minutes, with good stirring, an addition made dropwise of 12.5 g of a 30% formaldehyde solution. The reaction mixture is subsequently stirred for 15 hours at 45° C. After cooling, the precipitate is filtered off under suction, washed with water, dried, and recrystallised from toluene/hexane to obtain 1-cyanomethyl-2,2,6,6-tetramethyl-1-aza-4-thiacyclohexane-4,4-dioxide (11), M.P. 188° C.

Provenance & Evidence