Cyclohexyl isocyanate → HCID 12608488, compound

HRID 460782Notes

Reaction equation

HRID 460782 reaction equation
O.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:5][CH2:4]1.[CH:20]1([N:26]=[C:27]=[O:28])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C1C=CC=CC=1>[NH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH2:10][CH2:9][N:6]2[CH2:7][CH2:8][CH:3]([NH:2][C:27]([NH:26][CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:28])[CH2:4][CH2:5]2)=[CH:12]1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 203843533-[2-(4-Aminopiperidyl)ethyl]indole, hydrate

Product 1

HCID 12608488HCID 12608488, compoundYield 102.7%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

4-Amino-1-[2-(3-indolyl)ethyl]piperidine, hydrate (1.307 g, 0.005 mole) in benzene (50 ml.) was treated with cyclohexyl isocyanate (0.688 g, 0.0055 mole) and the mixture stirred for 18 hrs. Filtration afforded the title compound as colourless prisms (1.893 g), m.p. 203.8°.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-ec779a2ea7054514967842387d0594d6
Source dataset
uspto-grants-1977_12
Patent number
US04061641

Reaction notes

Loading…