Ethanol → HCID 12608576, compound

HRID 460789Notes

Reaction equation

HRID 460789 reaction equation
C([NH:9][C:10]([NH:12][CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][C:22]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[NH:26][CH:25]=2)=[O:23])[CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1.[OH-].[Na+].C(O)C>O>[NH:26]1[C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:24]([C:22](=[O:23])[CH2:21][CH2:20][CH2:19][N:16]2[CH2:15][CH2:14][CH:13]([NH:12][C:10]([NH2:9])=[O:11])[CH2:18][CH2:17]2)=[CH:25]1

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 12608535HCID 12608535, compound

Product 1

HCID 12608576HCID 12608576, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

1-Benzoyl-3-[1-(4-[3-indolyl]-4-oxobutyl)piperid-4-yl]urea free base (2.9g), sodium hydroxide (0.54g), ethanol (15ml) and water (5ml) were refuxed for two hours and then poured into cold water, the precipitated solid was filtered off and crystallised from ethanol to give 1-[1-(4-[3-indolyl]-4-oxobutyl)piperid-4-yl]urea.

Workup

  1. filtrationthe precipitated solid was filtered off
  2. customcrystallised from ethanol

Sources & evidence

ORD record
ord-5106e2ff8c1a4b93953fab4d56ffd5c3
Source dataset
uspto-grants-1977_12
Patent number
US04061641

Reaction notes

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