Potassium Fluoride → HCID 21394860, compound

Participants

Reaction Steps

A solution of 1-nitro-2-tetradecanone (13.0 grams, 50 mmoles) in tertiary butanol (75 milliliters, 0.95 mole) containing anhydrous potassium fluoride (0.2 gram, 3.44 mmoles) was refluxed for 3 hours with the slow removal of 25 milliliters of tertiary butanol. The residual solvent was stripped from the reaction mixture by evaporation at 30°-35° C. under a reduced pressure of 30 millimeters. The evaporation residue was recrystallized from petroleum ether to afford 4.4 grams of 3-tridecanoyl-4-nitro-5-dodecylisoxazole having a melting point of 60°-62° C.

Provenance & Evidence