Ethylenethiourea → 3-(2,4-Dichloro-5-sulfamoylphenyl)-3-hydroxy-2,3,5,6-tetrahydroimidazo[2,1-b]-thiazole-hydrobromide

HRID 460819Notes

Reaction equation

HRID 460819 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([Cl:15])=[CH:7][C:6]=1[Cl:16])=[O:4].[NH:17]1[CH2:21][CH2:20][NH:19][C:18]1=[S:22]>>[BrH:1].[Cl:16][C:6]1[CH:7]=[C:8]([Cl:15])[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:10][C:5]=1[C:3]1([OH:4])[CH2:2][S:22][C:18]2=[N:17][CH2:21][CH2:20][N:19]12

Participants

3

Reactant 2

HCID 2723650EthylenethioureaHCID 227564292-Bromo-2',4'-dichloro-5'-sulfamoylacetophenone

Product 1

HCID 213947293-(2,4-Dichloro-5-sulfamoylphenyl)-3-hydroxy-2,3,5,6-tetrahydroimidazo[2,1-b]-thiazole-hydrobromide

Procedure

was obtained in a manner analogous to the method described in Example 4 e from 3.5 g of 2-bromo-2',4'-dichloro-5'-sulfamoylacetophenone and 1 g of imidazolidine-2-thione. Mp. 225° C (decomposition).

Workup

  1. customwas obtained in a manner analogous to the method

Sources & evidence

ORD record
ord-fba9c03275174740ae06e413acb2da8e
Source dataset
uspto-grants-1977_12
Patent number
US04061647

Reaction notes

Loading…