3-Benzyl-1-methylthiourea → 2-Benzylimino-4-(2,4-dichloro-5-sulfamoylphenyl)-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

HRID 460824Notes

Reaction equation

HRID 460824 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([Cl:15])=[CH:7][C:6]=1[Cl:16])=[O:4].[CH2:17]([NH:24][C:25]([NH:27][CH3:28])=[S:26])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[BrH:1].[CH2:17]([N:24]=[C:25]1[N:27]([CH3:28])[C:3]([C:5]2[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([Cl:15])=[CH:7][C:6]=2[Cl:16])([OH:4])[CH2:2][S:26]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 27354893-Benzyl-1-methylthioureaHCID 227564292-Bromo-2',4'-dichloro-5'-sulfamoylacetophenone

Product 1

HCID 213947512-Benzylimino-4-(2,4-dichloro-5-sulfamoylphenyl)-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

Procedure

was obtained in a manner analogous to the method described in Example 10 from 3.5 g of 2-bromo-2',4'-dichloro-5'-sulfamoylacetophenone and 1.8 g of 1-benzyl-3-methyl-thiourea. Mp. 173° C (decomposition).

Workup

  1. customwas obtained in a manner analogous to the method

Sources & evidence

ORD record
ord-9e8c10447a934e98b43515441e25b5e5
Source dataset
uspto-grants-1977_12
Patent number
US04061647

Reaction notes

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