1-Ethyl-3-isobutyl-thiourea → 3-Ethyl-4-(3,4-dimethyl-5-sulfamoylphenyl)-2-isobutylimino-1,3-thiazolidine-4-ol-hydrobromide

HRID 460829Notes

Reaction equation

HRID 460829 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([CH3:15])=[C:7]([CH3:16])[CH:6]=1)=[O:4].[CH2:17]([NH:19][C:20]([NH:22][CH2:23][CH:24]([CH3:26])[CH3:25])=[S:21])[CH3:18]>>[BrH:1].[CH2:17]([N:19]1[C:3]([C:5]2[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([CH3:15])=[C:7]([CH3:16])[CH:6]=2)([OH:4])[CH2:2][S:21][C:20]1=[N:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH3:18]

Participants

3

Reactant 2

HCID 196505961-Ethyl-3-isobutyl-thioureaHCID 213947832-Bromo-3',4'-dimethyl-5'-sulfamoylacetophenone

Product 1

HCID 213948033-Ethyl-4-(3,4-dimethyl-5-sulfamoylphenyl)-2-isobutylimino-1,3-thiazolidine-4-ol-hydrobromide

Procedure

was obtained in a manner analogous to the method described in Example 6 from 3.1 g of 2-bromo-3',4'-dimethyl-5'-sulfamoylacetophenone and 1.7 g of 1-ethyl-3-isobutyl-thiourea. M.p. 145° C (decomposition).

Workup

  1. customwas obtained in a manner analogous to the method

Sources & evidence

ORD record
ord-7a7a34156a9242438fbea15a07ac6d17
Source dataset
uspto-grants-1977_12
Patent number
US04061647

Reaction notes

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