N,N'-Dimethylthiourea → HCID 21394790, compound

HRID 460833Notes

Reaction equation

HRID 460833 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([CH3:15])=[C:7]([Cl:16])[CH:6]=1)=[O:4].[CH3:17][NH:18][C:19]([NH:21][CH3:22])=[S:20]>>[BrH:1].[Cl:16][C:7]1[CH:6]=[C:5]([C:3]2([OH:4])[CH2:2][S:20][C:19](=[N:18][CH3:17])[N:21]2[CH3:22])[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]=1[CH3:15]

Participants

3

Reactant 2

HCID 2723631N,N'-DimethylthioureaHCID 21394772HCID 21394772, compound

Product 1

HCID 21394790HCID 21394790, compound

Procedure

3.2 g of 2-bromo-3'-chloro-4'-methyl-5'-sulfamoyl-acetophenone were reacted according to the method described in Example 6 with 1.2 g of 1,3-dimethyl-thiourea to yield the 4-(3-chloro-4-methyl-5-sulfamoylpheny)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hyrobromide. M.p. 160° C (decomposition).

Sources & evidence

ORD record
ord-95e243b2906f42f8ae49a454d2893d2c
Source dataset
uspto-grants-1977_12
Patent number
US04061647

Reaction notes

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