HCID 22759231, compound → HCID 22759300, compound

HRID 460860Notes

Reaction equation

HRID 460860 reaction equation
[C:1]([CH:4]([CH2:21][CH2:22][CH2:23][CH:24]([OH:34])[CH2:25][O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC1C=CC=CC=1)=[O:12])(=[O:3])[CH3:2].C(C(CCCC(O)COC1C=CC(F)=CC=1)CCCCCCC(O)=O)(=O)C>>[C:1]([CH:4]([CH2:21][CH2:22][CH2:23][CH:24]([OH:34])[CH2:25][O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 22759231HCID 22759231, compoundHCID 22759241HCID 22759241, compound

Product 1

HCID 22759300HCID 22759300, compound

Procedure

The synthesis of this compound is carried out by the hydrolytic procedure of Example 1, Step F, except that an equivalent quantity of benzyl 8-acetyl-12-hydroxy-13-benzyloxytridecanoate is substituted for the ethyl 8-acetyl-12-hydroxy-13-(4-fluorophenoxy)tridecanoate of Example 1, Step F. The title compound is purified by chromatography on silica gel with 3% methanol in chloroform as eluant.

Workup

  1. customThe synthesis of this compound
  2. customThe title compound is purified by chromatography on silica gel with 3% methanol in chloroform as eluant

Sources & evidence

ORD record
ord-7834da46357b46f78f3f5770b24a41e0
Source dataset
uspto-grants-1977_12
Patent number
US04061643

Reaction notes

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