HuagongsheHuagongshe Chemistry Print Report · For research reference only
beta-Aminobeta-ethoxyacrylic acid ethyl ester → 3-Amino-1-(4-fluorobenzyl)-pyrazol-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | beta-Aminobeta-ethoxyacrylic acid ethyl ester | HCID 278451 | — |
| Reactant | (4-Fluorobenzyl)hydrazine | HCID 15163346 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-1-(4-fluorobenzyl)-pyrazol-5-one | HCID 20367185 | — |
Reaction Steps
17.5 g of β-amino-β-ethoxyacrylic acid ethyl ester and 13 g of 4-fluorobenzylhydrazine, on stirring for 5 hours in ethanol at 60° and working up as described in Example 1, yield 13.2 g of the compound identified above as colorless crystals of melting point 148°, corresponding to 63% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04061653 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-698fa614f0434ffcaefd80daadc91bad |
| Source note | uspto-grants-1977_12 |