HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 20367296, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | beta-Aminobeta-ethoxyacrylic acid ethyl ester | HCID 278451 | — |
| Reactant | [(2-Chloro-4-fluorophenyl)methyl]hydrazine | HCID 16773950 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20367296 | HCID 20367296 | — |
Reaction Steps
53.8 g of 2-chloro-4-fluorobenzylhydrazine were added dropwise, under nitrogen, to a solution of 49.2 g of β-amino-β-ethoxyacrylic acid ethyl ester and 1 g of p-toluenesulphonic acid in 250 ml of ethanol, in the course of which the temperature rose from 22° to 32° C. After standing overnight, the compound identified above, which had separated out as a precipitate, was filtered off and recrystallised from ethanol. Melting point: 192°, 25 g (34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04061653 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-8efc5350fb25438b986771e3a7a193d6 |
| Source note | uspto-grants-1977_12 |