(4-methoxybenzyl)hydrazine → 3-Amino-1-(4-methoxybenzyl)-pyrazol-5-one

HRID 460926Notes

Reaction equation

HRID 460926 reaction equation
C([O:3][C:4](=O)[CH:5]=[C:6]([NH2:10])OCC)C.[CH3:12][O:13][C:14]1[CH:22]=[CH:21][C:17]([CH2:18][NH:19][NH2:20])=[CH:16][CH:15]=1>>[NH2:10][C:6]1[NH:20][N:19]([CH2:18][C:17]2[CH:21]=[CH:22][C:14]([O:13][CH3:12])=[CH:15][CH:16]=2)[C:4](=[O:3])[CH:5]=1

Participants

3

Reactant 2

HCID 16194(4-methoxybenzyl)hydrazineHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl ester

Product 1

HCID 203673273-Amino-1-(4-methoxybenzyl)-pyrazol-5-one

Procedure

From 17.5 g of β-amino-β-ethoxyacrylic acid ethyl ester and 15.2 g of 4-methoxybenzylhydrazine, analogously to the procedure described in Example 45, 9.7 g of the compound identified above, as colorless crystals of melting point 161°, corresponding to 44% of theory, are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-12a7326539f94751a490157690d80cf5
Source dataset
uspto-grants-1977_12
Patent number
US04061653

Reaction notes

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