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1-(3-Chloropropyl)-4-phenylpiperidine → 3-[3-(4-Phenyl-1-Piperidyl)Propyl]-5-Phenyl-5-(2-Pyridyl)Hydantoin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Chloropropyl)-4-phenylpiperidine | HCID 203689 | — |
| 反応物 | Mls002667559 | HCID 243331 | — |
| 反応物 | 3-[2-(4-Phenyl-1-piperidyl)ethyl]-5-phenyl-5-(2-pyridyl)-hydantoin | HCID 21395252 | — |
| 反応物 | 1-(Chloromethyl)-4-phenyl-piperidine | HCID 21395258 | — |
| 生成物 | 3-[3-(4-Phenyl-1-Piperidyl)Propyl]-5-Phenyl-5-(2-Pyridyl)Hydantoin | HCID 21395246 | — |
反応手順
Analysis -- Calculated for C32H34N4O6 : C, 67.36; H, 6.00; N, 9.82. Found: C, 67.60; H, 6.16; N, 10.01. Substitution of 1-(2-chloroethyl)-4-phenyl-piperidine or 1-(chloromethyl)-4-phenyl-piperidine for 1-(3-chloropropyl)-4-phenyl-piperidine in the above example respectively yields: 3-[2-(4-phenyl-1-piperidyl)ethyl]-5-phenyl-5-(2-pyridyl)-hydantoin and 3-[(4-phenyl)-1-piperidyl)methyl]-5-phenyl-5-(2-pyridyl)-hydantoin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04061760 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-b074d2de300e4146b794382135c2ffdc |
| 出典メモ | uspto-grants-1977_12 |