HuagongsheHuagongshe Chemistry Print Report · For research reference only
2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → N-[(1R,2R)-2-phenylcyclopentyl]azepan-2-imine;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- | HCID 75657 | — |
| Reactant | rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride | HCID 70051154 | — |
| Catalyst | Ethanol | HCID 702 | — |
| Product | N-[(1R,2R)-2-phenylcyclopentyl]azepan-2-imine;hydrochloride | HCID 145795653 | — |
Reaction Steps
A mixture of 4.0 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 205°-206° C and 5.0 ml of O-methylcaprolactim is allowed to stand at room temperature for 6 days with occasional stirring. A few drops of ethanol are added to maintain a stirrable slurry, after which the mixture is cooled. The resulting solid is washed with ether and recrystallized from acetone/methanol to give the desired product, M.P. 181.5°-183.5° C (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04061746 |
| Source dataset | uspto-grants-1977_12 |
| ORD ID | ord-9dcbb9a606b14c8c9b3bed0db9e363fa |
| Source note | uspto-grants-1977_12 |