Sodium Hydroxide → HCID 54325626, compound

Participants

Reaction Conditions

Reaction Steps

2 g of 2-phenyl-3-(4-bromophenyl)-3-chloro-acrylaldoxime (5.9 mmoles) were suspended in 50 ml of THF. The mixture was cooled to 0° C and, successively, 5 ml of sodium hydroxide solution and 1.14 g of p-toluene-sulfochloride were added. The mixture was stirred for 1 hour at 10° C and evaporated at room temperature. The solid residue was taken up with a small amount of methylene chloride and applied onto a column with basic aluminum oxide in n-hexane. Elution was effected with petroleum ether and then with methylene chloride. In this way pure 2-phenyl-3-(4-bromophenyl)-3-chloro-acrylonitrile (melting point: 128°-130° C) was obtained.

Provenance & Evidence