Pyridine → 2-Methyl-3-hydroxy-4-acetyl-5-vinylpyridine

HRID 461058Notes

Reaction equation

HRID 461058 reaction equation
N1C=CC=CC=1.[CH3:7][C:8]1[C:13]([OH:14])=[C:12]([CH:15]([OH:17])[CH3:16])[C:11]([CH:18]=[CH2:19])=[CH:10][N:9]=1>[O-2].[O-2].[O-2].[Cr+6].C(Cl)Cl>[CH3:7][C:8]1[C:13]([OH:14])=[C:12]([C:15](=[O:17])[CH3:16])[C:11]([CH:18]=[CH2:19])=[CH:10][N:9]=1

Participants

5

Reactant 2

HCID 1049PyridineHCID 202639212-Methyl-3-hydroxy-4-(1-hydroxyethyl)-5-vinylpyridine

Product 1

HCID 202640462-Methyl-3-hydroxy-4-acetyl-5-vinylpyridine

Reagents, catalysts & solvents 2

HCID 10219390chromium (VI) trioxideCatalystHCID 6344DichloromethaneSolvent2×

Procedure

To 750 ml. of dry methylene chloride containing 47.5 ml. of dry pyridine was added with stirring and cooling 29.6 g. of chromium trioxide. The mixture was aged 20 minutes at room temperature and then treated with a solution of 10.96 g. of the product from Example 10, Step B, in 250 ml. of dry methylene chloride over 15 minutes. After one hour at room temperature, the reaction mixture was filtered and the residue was washed with 2 × 100 ml. of methylene chloride. The methylene chloride filtrates were extracted with 3 × 500 ml. of 5% (w/w) aqueous sodium hydroxide solution, dried over magnesium sulfate and evaporated to dryness. The residue was crystallized from hexane to give 2-methyl-3-hydroxy-4-acetyl-5-vinylpyridine.

Workup

  1. temperaturecooling 29.6 g
  2. additiontreated with a solution of 10.96 g
  3. waitAfter one hour at room temperature
  4. filtrationthe reaction mixture was filtered
  5. washthe residue was washed with 2 × 100 ml
  6. extractionThe methylene chloride filtrates were extracted with 3 × 500 ml
  7. dry with materialof 5% (w/w) aqueous sodium hydroxide solution, dried over magnesium sulfate
  8. customevaporated to dryness
  9. customThe residue was crystallized from hexane

Sources & evidence

ORD record
ord-dd0a8056e64644bb81a1ebd3e605352e
Source dataset
uspto-grants-1977_12
Patent number
US04061759

Reaction notes

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